What I want to accomplish:

dct = {'foo':0, 'bar':1, 'baz':2}
def func(**dct):pass
#function signature is now func(foo=0, bar=1, baz=2)

However, the ** syntax is obviously clashing here between expanding a dict (what I want to do) and declaring a parameter that holds the keyword arguments (what I don't want to do).

Is this possible?

Based on my interpretation of your requirements -- you want to dynamically define a function with a signature that matches the content of adict provided at runtime -- there are two issues here which makes it impractical.

1. If the arguments are defined at run-time, how can your function reference the variables? Are you planning to build the function body at run-time as well?
2. dicts are unordered, so you cannot reliably use them to define positional arguments

I suspect this is an XY problem. If you can explain what you're trying to achieve then perhaps we can be of better help.

However, assuming you're trying to assign default keyword arguments using a dict then one way to achieve this would be to use decorators. For example:

def defaultArgs(default_kw):"decorator to assign default kwargs"def wrap(f):def wrapped_f(**kwargs):kw = {}kw.update(default_kw)  # apply defaultskw.update(kwargs)  # apply from input argsf(**kw)  # run actual function with updated kwargsreturn wrapped_freturn wrap

You can then use this decorator to assign default keyword arguments to a function that expects only keyword arguments:

defaults = {'foo':0, 'bar':1, 'baz':2}@defaultArgs(defaults)
def func(**kwargs):print kwargs  # args accessible via the kwargs dict

Results:

func()  # prints {'baz': 2, 'foo': 0, 'bar': 1}
func(foo=2)  # prints {'baz': 2, 'foo': 2, 'bar': 1}params = {'bar':1000, 'hello':'world'}
func(**params)  # prints {'baz': 2, 'foo': 0, 'bar': 1000, 'hello': 'world'}

Note that you will not be able to use positional arguments:

func(1, 2, 3)   # raises TypeError