I'm coming from Snow Leopard at work to a Lion installation at home. I do NOT remember having to:

sudo easy_install pip

Is that required for Lion? I got errors until I did that, and pip ended up here:

[ some@computer ] ~ $ which pip
/usr/local/bin//pip

Does this mean that I'm going to have to sudo pip install other packages? e.g.:

sudo pip install virtualenv
sudo pip install virtualenvwrapper

I should also note that I'm running XCode 4.3 with the new separate install of the command line tools. So I do NOT have a /Developer path right now on my OS X Lion volume.

Yes. Generally you sudo to use pip. You could change a bunch of permissions and you may not have to but that could break all sorts of things. If you want to avoid re-typing your password try opening a

"sudo screen" session first. Then your shell will be logged in as root and will not prompt for the password. (Using sudo screen will allow you to run pip and other admin commands without typing sudo again)